Optimization study on Niosome Loaded Ficus Deltodia Extract.

¹ Food and Nutraceutical Unit, Institute of Bioproduct Development, Universiti Teknologi Malaysia, 81310, Johor Bahru, Johor, Malaysia
² Department of Bioprocess Engineering, Faculty of Chemical and Energy Engineering, Universiti Teknologi Malaysia, 81310, Johor, Malaysia.

^* Corresponding author : harisun@ibd.utm.my

Abstract

Ficus deltoidea (FD) plant extract is not able to cross the lipidic biomembranes of the skin as they are hydrophilic in nature. In order to overcome this problem FD were encapsulated with noisome, a novel lipid delivery system that potentially increases the absorption. This research study on optimum formulation and process condition of niosome loaded FD extract. The factors involved in formulation were amount of Span 60, amount of cholesterol and amount of Labrasol. Their corresponding responses for the design were entrapment efficiency (EE), particle size (PS) and zeta potential (ZP). The optimum formulation obtained were 0.6 mmol of Span 60, 0.4 of mmol Cholesterol, and 0.1 mmol of Labrasol. Results obtained showed improved activity on skin penetration compared to free FD.