| Issue |
MATEC Web Conf.
Volume 154, 2018
The 2nd International Conference on Engineering and Technology for Sustainable Development (ICET4SD 2017)
|
|
|---|---|---|
| Article Number | 04003 | |
| Number of page(s) | 6 | |
| Section | Life Sciences | |
| DOI | https://doi.org/10.1051/matecconf/201815404003 | |
| Published online | 28 February 2018 | |
Antiproliferative activity of natural coumarins from Calophyllum incrasaptum M.R Henderson-Wyatt Smith against human breast cancer cells MCF
Research Center for Chemistry, Indonesian Institute of Sciences (LIPI). PUSPIPTEK, Serpong, 15314, Indonesia
* Corresponding author: jamilahabbas@yahoo.com.
Objective: to evaluated the antiproliferative activity of natural coumarin from Calophyllum incrasaptum M.R Henderson-Wytt Smith against human breast cancer cells MCF-7. Methode : Coumarin from ethyl acetate fraction of C. incrasaptum M.R Henderson-Wyatt Smith was isolated by coloumn chromatographyic and structure elucidated by using spectroscopic methods and isolate compound was evaluated for their antiproliferative activities in the alamar blue assay. Result: Coumarin have antiproliferative activity against MCF-7 cancer cell lines through alamar blue assay for 4 h after treatment. Conclusions: coumarin showed good activity against cancer cell lines with IC50 value of 2.23 μg/mL.
Key words: antiproliferative / C. incrasaptum M.R Henderson-Wyatt Smith / MCF-7
© The Authors, published by EDP Sciences, 2018
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (http://creativecommons.org/licenses/by/4.0/).
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