Burn drug made from ozonated vegetable oil mixture with white tumeric and cassava leaves extract

Chemical Engineering Department, Universitas Indonesia, Kampus Baru UI Depok, Depok 16424, Indonesia

^* Corresponding author: sbismo@che.ui.ac.id

Abstract

This research aims to create a burn treatment performed with ozonation process from a mixture of vegetable oil and added extracts of herbal ingredients. Ozonation on vegetable oils proven to kill bacteria and safe for the body. Ozonated vegetable oil produced from the ozone reactor batch process by doing a variety of extraction mixture to Oleozon® and vegetable oils. Then the results of ozonation is added extracts of herbal ingredients that cassava leaves and white turmeric to increase effectiveness in killing bacteria. Cassava leaves have anti-inflammatory agent, namely Vitamin C. While white turmeric Curcuma zedoaria have substance, which of the two compounds can inhibit and kill bacteria. The quality of ozonated oil (Oleozon®) analytically were tested by the method of iodine number, acid number, peroxide number, and FTIR. Ozonation increased the peroxide and acid values for both oils, the increase being higher for mixture of coconut oil and soybean oil. The results of such mixing is then tested in bacteria to determine their effectiveness in killing the bacteria. The best ozonation condition is in an increase of 386,85% acid value, peroxide value about 102,91 meq/kg oil, and decrease in iodine number up to 21%. The result showed that under these conditions, ozonized oil has an antiseptic effect against Staphylococcus aureus. The final results of this study are expected to be a new innovation in the healing of skin wounds caused by burns as an anti-inflammatory that is effective, safe, and environmentally friendly.