Research on the platform of combined multi-functional bioreactor loading performance

Tianjin Key Laboratory of the Design and Intelligent Control of the Advanced Mechatronical System, School of Mechanical Engineering, Tianjin University of Technology, Tianjin 300384, China

Abstract

Mechanical environment plays an important role in the growth of cells, tissues and organs, in the study of mechanobiology and tissue engineering, and loading bioreactor acts as the basic platform. We developed a combined multi-functional bioreactor based on linear motor, and studied on the loading performance of different modules and loading methods. In the rolling / sliding loading module, in the effective distance for 50mm case, the bioreactor frequency is 0.01Hz to 0.3Hz. Under tensile and compressive loading module, the minimum amplitude of the bioreactor can reached 0.01mm while the frequency can reach 10Hz. Under the impact test module, in the effective distance for 50mm case, acceleration a=54.16m/s2 can be realized. In the high acceleration cyclic loading module, acceleration 8Gcan be realized. The combined multi-functional bioreactor provides conditions for the study related mechanobiology and tissue engineering.