MATEC Web Conf.
Volume 237, 20182018 3rd International Conference on Design, Mechanical and Material Engineering (D2ME 2018)
|Number of page(s)||6|
|Section||Chapter 2: Material Engineering|
|Published online||26 November 2018|
Swelling Properties of Propranolol HCl-loaded Polyvinyl Alcohol-graft-lactic Acid Hydrogel Films
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Rangsit University, Pathum Thani, Thailand
2 Department of Pharmacognosy, College of Pharmacy, Rangsit University, Pathum Thani, Thailand
This paper presented the swelling properties of propranolol HCl-loaded polyvinyl alcohol-graft-lactic acid (PPH-loaded PVA-g-LA) hydrogel films. The swelling properties including swelling-deswelling measurement and swelling behaviour in different environmental stimuli fluids such as water, various pH, and various ionic strength were determined. It was found that the swelling properties of the PPH-loaded PVA-g-LA hydrogel films depend on the LA amount addition. They had a good swelling and deswelling in water and acetone. The PPH-loaded PVA-g-LA hydrogel films showed the high swelling in the medium pH 7. Thus, the prepared PPH-loaded PVA-g-LA hydrogel films had a good swelling property that could be used to controlled drug release in pharmaceutical product.
© The Authors, published by EDP Sciences, 2018
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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