| Issue |
MATEC Web Conf.
Volume 154, 2018
The 2nd International Conference on Engineering and Technology for Sustainable Development (ICET4SD 2017)
|
|
|---|---|---|
| Article Number | 04005 | |
| Number of page(s) | 7 | |
| Section | Life Sciences | |
| DOI | https://doi.org/10.1051/matecconf/201815404005 | |
| Published online | 28 February 2018 | |
Rheumatoid arthritis and the challenge of using nanoparticles for its treatment
1
Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, 55281, Indonesia
2
Department of Pharmacy, Islamic University of Indonesia, Yogyakarta, 55584, Indonesia
3
School of Pharmacy Mahaganesha, Denpasar, Bali, 80226, Indonesia
4
Chemical Engineering Department, Islamic University of Indonesia, Yogyakarta, 55584, Indonesia
* Corresponding author: lutfi.chabib@uii.ac.id
Rheumatoid arthritis is the most common autoimmune disease that affects the joints. The cause of the disease is unknown, many studies proposed hypothesis about the etiology of rheumatoid arthritis. The clinical manifestations of arthritis are different in each patients. In addition, the development of the medication is still continue to achieve the most effective role with less side effect. Nanoparticles may be the answer to this problem, since they have been widely used to improve the pharmacokinetic and pharmacodynamics of rheumatoid arthritis drugs. Using nanoparticles-tagged folate or PEG to deliver rheumatoid arthritis drugs may increase the specificity of the drugs to the target and consequently, may decrease the side effects of the drugs. The purpose of this review is to summarize the etiology, clinical manifestation and highlighting the use of nanoparticles in rheumatoid arthritis treatment.
© The Authors, published by EDP Sciences, 2018
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (http://creativecommons.org/licenses/by/4.0/).
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