Scale Up Production Indonesian Liquid Propolis From Raw Propolis and Wild Beehive Using Bubbling Vacuum Evaporator

¹ Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16425, West java, Indonesia
² Research Center of Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16425, West java, Indonesia
³ Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Pancasila University. South Jakarta, 12640, DKI Jakarta, Indonesia

^* Corresponding author: sahlan@che.ui,ac.id

Abstract

The process of production propolis on a laboratory scale using a rotary evaporator with capacity one liter of ethanol extract propolis include propylene glycol as solvent medium. Ethanol is evaporated at a temperature of 65°C and reduced water content at 80°C. For the quantity of products can be increased by increasing the capacity of the ethanol extract of propolis and the medium while solvent evaporation to 12 liters and modify the rotary system with a bubbling system (bubbling vacuum evaporator). Then the solvent medium used was replaced with glycerol. The result of 8.02 kg of raw propolis produced 10.85 liters with the average of total flavonoid content 914.8 mg/l, while for 8 kg of raw material forest beehive produced 7.65 liters with the average of total flavonoid content 307.2 mg/l. With the capacity production average reaches one liter per day. The resulting product by organoleptically sweet taste, no smell and distinctive of saliva and the color of the product are brown.