| Issue |
MATEC Web Conf.
Volume 376, 2023
Conference on Advanced Materials for Engineering and Functional Purposes (AMEFP 2022)
|
|
|---|---|---|
| Article Number | 01001 | |
| Number of page(s) | 7 | |
| Section | Advanced Materials Technologies and Application | |
| DOI | https://doi.org/10.1051/matecconf/202337601001 | |
| Published online | 13 April 2023 | |
Development of chitosan nanoparticles for anticancer drug delivery systems
Institute of Life Sciences and Biomedicine, Far Eastern Federal University, Vladivostok 690922, Russia
* Corresponding author: vkumeiko@yandex.ru
Chitosan is a natural polymer that is often used in nanotechnology because it has such useful properties as biodegradability and biocompatibility. Chitosan has many benefits, but they are outweighed by drawbacks such insolubility, aggregation at physiological pH, and insufficient cargo release in the cytosol. In order to obtain chitosan nanoparticles that can be used as drug delivery systems, we optimized the synthesis technology by selecting MES buffer pH 6.3 and using a BSA coating step to reduce nanoparticle aggregation. Deposition of the chemotherapeutic agent etoposide in chitosan nanoparticles has been proven and confirmed by IR spectra, although future experiments are needed to tune conditions for stronger interactions. The chitosan nanoparticles that we have obtained can become suitable nanomaterials for biomedical applications as promising carriers for drug delivery.
© The Authors, published by EDP Sciences, 2023
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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