| Issue |
MATEC Web Conf.
Volume 197, 2018
The 3rd Annual Applied Science and Engineering Conference (AASEC 2018)
|
|
|---|---|---|
| Article Number | 03009 | |
| Number of page(s) | 5 | |
| Section | Computer Science | |
| DOI | https://doi.org/10.1051/matecconf/201819703009 | |
| Published online | 12 September 2018 | |
Insilico docking studies of daidzeion compounds as selective estrogen receptor modulator (SERMS) breast cancer
1
UIN Sunan Gunung Djati Bandung, Department of Biology, 40614, West Java, Indonesia
2
UIN Sunan Gunung Djati Bandung, Department of Biology Education, Bandung 40614, West Java, Indonesia
* Corresponding author: yan_dhika@yahoo.com
The aims of this study to analyze the potential of daidzein compounds as selective estrogen receptor modulators (SERMs) compared with 17-β estradiol. SERMs is a compound that can be used as a anticancer of breast cancer. The process of analysis is done computation, that is molecular docking. The research was conducted at Data Processing Laboratory of Department of Biology Faculty of Science and Technology, State Islamic University of Sunan Gunung Djati Bandung in December 2017 until February 2018. The result of analysis showed that daidzein compounds have excellent potential as SERMs. This is indicated by the very low energy value of binding affinity of Deidzein (-9.4 kcal / mol) compared to17-β estradiol (-8.9 kcal / mol). The smallest of energy binding affinity value indicates a very high binding ability.
© The Authors, published by EDP Sciences, 2018
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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