| Issue |
MATEC Web Conf.
Volume 156, 2018
The 24th Regional Symposium on Chemical Engineering (RSCE 2017)
|
|
|---|---|---|
| Article Number | 01021 | |
| Number of page(s) | 5 | |
| Section | Biochemical and Biomedical Engineering | |
| DOI | https://doi.org/10.1051/matecconf/201815601021 | |
| Published online | 14 March 2018 | |
Performance of Deacetyled Glucomannan as Iron Encapsulation Excipient
1
Chemical Engineering Department, Faculty of Engineering, Diponegoro University, Semarang, Indonesia
2
Public Health Department, Diponegoro University-Semarang, Indonesia
* Corresponding author: dhwardhani@che.undip.ac.id
Encapsulation protects iron from degradation or oxidation possibilities due to its encapsulation material. Glucomannan (GM) is a neutral polysaccharide consist of D-mannose and D-glucose connected with β-1,4 linkage. Deactylation transforms solubility of glucomannan as well as its gel structure. These properties support for excipient application. The aim of this work was to determine performance of deacetylated glucomannan as iron matrix. Deacetylation was conducted heterogeneously. Deacetylation did not change the backbone of GM. Higher alkali concentration has better ability to encapsulate iron. Extended deacetylation time and alkali concentration affect insignificantly on the performance of encapsulation to protect iron from oxidation. The release of iron from the matrix influences by deacetylation degree.
© The Authors, published by EDP Sciences, 2018
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (http://creativecommons.org/licenses/by/4.0/).
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