MATEC Web Conf.
Volume 87, 2017The 9th International Unimas Stem Engineering Conference (ENCON 2016) “Innovative Solutions for Engineering and Technology Challenges”
|Number of page(s)||6|
|Published online||12 December 2016|
Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones
1 Department of Mechanical and Manufacturing Engineering, Faculty of Engineering, Universiti Malaysia Sarawak (UNIMAS), 94300 Kota Samarahan, Sarawak, Malaysia
2 Department of Chemistry, The Islamia University of Bahawalpur, Pakistan
3 Department of chemistry, Faculty of Resource Science & Technology Universiti Malaysia Sarawak (UNIMAS), 94300 Kota Samarahan, Sarawak, Malaysia
A general, simple, efficient, cost-effective and environmental benign procedure for the syntheses of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones (DHPMs) has been developed. The reaction is efficiently catalysed by using various amino acids viz., glycine, L-proline, L-cysteine, leucine and tryptophan. Reactions give excellent yields under reflux conditions. The chemical structures of these compounds were identified by Fourier Transform-Infra Red Spectroscopy (FT-IR), Gas Chromatography-Mass Spectroscopy (GC-MS) and Nuclear Magnetic Resonance Spectroscopy (1H NMR). Physical parameters such as m.p., mixed m.p. as well as TLC also helped to characterize the expected products. The progress of the reaction time and purity was checked by TLC and the products were purified by recrystallization using ethyl acetate as a solvent. The synthesized molecule has numerous biological applications as it is anti-microbial, anti-inflammatory and anti-hypertensive in character.
Key words: Green Approach / Amino Acids / 4-Aryldihydropyrimidinone
© The Authors, published by EDP Sciences, 2017
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