MATEC Web Conf.
Volume 67, 2016International Symposium on Materials Application and Engineering (SMAE 2016)
|Number of page(s)||8|
|Section||Chapter 2 Electronic Technology|
|Published online||29 July 2016|
Biocompatible Fluorescent Probe with the Aggregation-induced Emission Characteristic for Live Cell Imaging
1 College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, P. R. China
2 Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding, 071002, P. R. China
3 Key Laboratory of Analytical Science and Technology of Hebei Province, Hebei University, Baoding, 071002, P. R. China
A new kind of biocompatible probe (PEG-TPEFE) with aggregation-induced emission (AIE) characteristic was reported, which was synthesized from fluorene, tetraphenylethylene (TPE) and polyethylene glycol monomethyle ether 1000 (PEG1000). PEGTPEFE can aggregate into nanosphere and emit strong blue fluorescence in aqueous media. Cytotoxicity assay reveals low cytotoxicity and excellent biocompatibility of this nanoprobe. This nanoprobe was internalized and accumulated by live cells and shown high photostability.
Key words: Fluorescent probe / aggregation-induced emission (AIE) / photophysical properties / cellular imaging
© The Authors, published by EDP Sciences, 2016
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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