| Issue |
MATEC Web of Conferences
Volume 39, 2016
2015 2nd International Conference on Chemical and Material Engineering (ICCME 2015)
|
|
|---|---|---|
| Article Number | 01003 | |
| Number of page(s) | 4 | |
| Section | Novel materials and properties | |
| DOI | https://doi.org/10.1051/matecconf/20163901003 | |
| Published online | 13 January 2016 | |
The synthesis and characterization of novel brush-type chiral stationary phase based on terpenoid selector for resolution of chiral drugs
1 College of Chemical Engineering, Sichuan University, 610065 Chengdu, China
2 Chengdu University of Traditional Chinese Medicine, 610075 Chengdu, China
a Corresponding author: hangsong@scu.edu.cn
In the light of the chiral resolution mechanism and structures of brush-type CSP, a new chiral selector 4′-carboxyl-1′-ursolic methyl ester-3β-yl-benzoate has been prepared. Then the terpenoid chiral selector was covalently linked to 3-aminopropyl silica gel. Its structure identification data are provided by 1H NMR, MS and elementary analysis. The enantiodiscriminating capability of the brush-type CSP was evaluated by static adsorption experiment with methyl mandelate, aniline derivative of mandelic acid, benzoin and ibuprofen. Experimental results demonstrated that the chiral selector has selectivity, and the enantiomers of methyl mandelate and ibuprofen could be separated on the CSP, which indicated that the novel brush-type CSP possess a bright prospects for chiral separation potentially.
© Owned by the authors, published by EDP Sciences, 2016
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