| Issue |
MATEC Web Conf.
Volume 404, 2024
2024 2nd International Conference on Materials Engineering, New Energy and Chemistry (MENEC 2024)
|
|
|---|---|---|
| Article Number | 04011 | |
| Number of page(s) | 6 | |
| Section | Pharmaceuticals, Environmental Science, and Toxicology | |
| DOI | https://doi.org/10.1051/matecconf/202440404011 | |
| Published online | 24 October 2024 | |
Toxic mechanism and detection methods of tetrodotoxin
School of Physical Sciences, University of California, Irvine, 92617 Irvine, USA
* Corresponding author: yunzhex1@uci.edu
Tetrodotoxin (TTX) was first isolated in the early 20th century and has significant public health implications, especially in areas where puffer fish are consumed, such as Japan. Research on TTX spans multiple disciplines, including toxicology, pharmacology, marine biology, and neurology, and efforts are underway to understand its mechanism of action, ecological roles, and biosynthesis. TTX exerts its toxic effects through selective blockade of voltage-gated sodium channels (VGSCs), leading to paralysis and potentially fatal respiratory failure. This research will discuss the toxic mechanism of TTX and analyze the existing detection methods for TTX. Despite advances in detection and diagnostic methods, there is currently no antidote for TTX poisoning and treatment remains adjunctive, and this has also become a development direction for future research. Understanding the ecological significance and potential therapeutic use of TTX is essential to reduce risk and harness its benefits. Continued research is aimed at developing effective treatments and preventive measures against TTX toxicity.
© The Authors, published by EDP Sciences, 2024
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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