| Issue |
MATEC Web Conf.
Volume 395, 2024
2023 2nd International Conference on Physics, Computing and Mathematical (ICPCM2023)
|
|
|---|---|---|
| Article Number | 01049 | |
| Number of page(s) | 6 | |
| DOI | https://doi.org/10.1051/matecconf/202439501049 | |
| Published online | 15 May 2024 | |
Neuroprotective effects of polysaccharide of Schisandrae Chinensis Fructus in aging mice
1 Basic Medical College, Jilin Medical University, Jilin Province, China
2 Basic Medical College of Beihua University, Jilin Province, China
3 College of Pharmacy, Jilin Medical University, Jilin Province, China
* Corresponding author: sunxinbh@126.com; lcythunder@163.com
# These authors contributed equally to this work
This study aimed to investigate the effects of Schisandra Chinensis Fructus polysaccharide (SCP) on learning and memory, hippocampal antioxidant activity and Keap1/Nrf2 signal transduction pathway in an aging mouse model. The step-down test was used to observe learning and memory. Biochemical analysis was used to detect Superoxide dismutase (SOD) and malondialdehyde (MDA) levels. Nrf2, HO-1, and Keap1 gene expression in the hippocampus were measured by quantitative real-time polymerase chain reaction (qRT-PCR). SCP can improve the learning and memory ability (P<0.05), increase hippocampal SOD activity, decrease MDA levels, up-regulate Nrf2 and HO-1 gene expressions, down-regulate Keap1 gene expression (P<0.05). Our findings suggest that SCP can improve brain damage in D-galactose-induced aging mice, improve antioxidant enzyme activity, reduce lipid peroxidation, and has obvious anti-aging effects. Its anti-aging activity may be related to activating the Keap1/Nrf2 signal transduction pathway in the hippocampus.
© The Authors, published by EDP Sciences, 2024
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.