MATEC Web Conf.
Volume 187, 20182018 4th International Conference on Chemical Materials and Process (ICCMP 2018)
|Number of page(s)||6|
|Section||Material Science and Engineering|
|Published online||06 August 2018|
The Antibacterial and Antioxidant Activity of Centella Asiatica Chloroform Extract-loaded Gelatin Nanoparticles
Food Biotechnology Department, Biotechnology Faculty, Assumption University, Bangkok, 10240, Thailand
2 The Sirindhorn International Thai-German Graduate School of Engineering, King Mongkut's University of Technology North Bangkok
3 Food Technology & Engineering Laboratory, Pilot Plant Development & Training Institute, King Mongkut's University of Technology Thonburi, Bangkok, Thailand
4 Food Biotechnology Department, Biotechnology Faculty, Assumption University, Bangkok, 10240, Thailand
Nanoencapsulation of Centella asaitica (CA) crude chloroform extract seems to be an attractive approach that may improve drug bioavailability and drug delivery system. In the study, CA extract-loaded gelatin nanoparticles (CGNP) were developed by gelatin one-step and two-step desolvation methods, using three different ratios between CA crude chloroform extract and gelatin (1:2, 1:3, and 1:4 w/w). The antibacterial and antioxidants activities of CGNP and CA were compared. The antioxidant activity of CGNP and CA was evaluated by using DPPH radical scavenging assay and ferric reducing antioxidant power (FRAP) assay. Results showed an enhancement of CGNP antibacterial activity against food borne pathogen. The highest inhibition diameters and FRAP determined from CGNP prepared by one-step at 1:4 ratios (1.03±0.39 cm and 1.23±019 mmol Fe2+/mg dried weight, respectively). However, CGNP was no significant difference in DPPH radical scavenging activity compared to CA. These results provide useful information for developing effective nanoencapsulation of CA as effective natural ingredient.
© The Authors, published by EDP Sciences, 2018
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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