MATEC Web Conf.
Volume 109, 20172017 2nd International Conference on Materials Science and Nanotechnology (ICMSNT 2017) – 2017 2nd International Symposium on Material Science and Technology (ISMST 2017)
|Number of page(s)||6|
|Section||Chapter 5: Modelling to Predict Mechanical Behaviours and Other Technologies|
|Published online||31 May 2017|
CXCL-8 Regulates Head and Neck Carcinoma Progression through NOD Signalling Pathway
1 Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
2 Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
3 Division of Plastic Surgery & HBOT Center, Chi Mei Medical Center, Tainan, Taiwan
4 Department of Electrical Engineering, Southern Taiwan University of Science & Technology
5 Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan
6 Department of Cosmetic Science and Institute of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
7 Department of Computer and Communication, Shu-Te University, Kaohsiung, Taiwan
a Corresponding author: firstname.lastname@example.org
Head and neck squamous cell carcinoma (HNSCC) ranks sixth among the most common cancers in the world. Interlukin-8 (CXCL-8), a major role in inflammatory response and tumor microenvironment, correlates with tumor progression, metastasis and invasion. We explored CXCL-8 promotes tumor progression in different differentiation HNSCC cells. This project would apply to development on biomarker and target in HNSCC as well as provide a basis of early diagnosis and treatment for clinical. CXCL-8, NOD1 (nucleotide-binding oligomerization domain-containing protein 1) and receptor-interacting protein kinase (RIPK2) levels were detected statistically higher in patient tissue with HNSCC than in non-cancerous matched tissue (NCMT) in the microarray and qRT-PCR study, whereas NOD2 was weakly expressed. Similar results were obtained for CXCL-8, NOD1, NOD2 and RIP2 from RT-PCR and western blotting. High CXCL-8, NOD1 and RIP2 expressions were found on HNSCC patient tissue than that of NCMT, whereas NOD2 was weakly expressed. The analytical results indicate that CXCL-8 is required in NOD 1-mediated signalling pathways in HNSCC.
© The Authors, published by EDP Sciences, 2017
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.