MATEC Web Conf.
Volume 79, 2016VII Scientific Conference with International Participation “Information-Measuring Equipment and Technologies” (IME&T 2016)
|Number of page(s)||6|
|Published online||11 October 2016|
Dynamic Single-Photon Emission Computed Tomography Data Analysis: Capabilities for Determining Functional Significance of Coronary Artery Atherosclerosis
1 Federal State Budgetary Scientific Institution “Research Institute for Cardiology”, 634012, Tomsk, Russia
2 National Research Tomsk Polytechnic University, 634050, Tomsk, Russia
* Corresponding author: firstname.lastname@example.org
The aim of the study was to develop the method for collecting and processing scintigraphic data to determine myocardial flow reserve by using gamma-camera with a new type detector based on Cadmium Zinc Telluride (CZT). Sixteen coronary artery disease patients and nine healthy volunteers received cardiac dynamic single-photon emission computed tomography with technetium 99m methoxyisobutylisonitrile (99mTc-MIBI) at rest and during pharmacologic stress test. Data processing involved a formation of regions of interest from the left ventricular (LV) cavity and myocardial walls to build activity-time curves. Myocardial flow reserve index was determined as a quotient of two ratios of mean myocardial counts to area under a curve peak from LV cavity during stress test and at rest. Mean values of myocardial flow reserve index were 1.86 (1.59; 2.2) in group of healthy volunteers and 1.39 (1.12; 1.69) in patients with multivessel coronary artery disease. When the value of this index was less than 1.77, the method allowed for identification of multivessel disease with sensitivity and specificity of 81.8% and 66.7%, respectively. Standard myocardial perfusion scintigraphy in combination with the method of myocardial flow reserve index determination allows for increasing diagnostic significance of the scintigraphic approach for assessment of coronary microcirculation lesions in multivessel coronary artery disease.
© The Authors, published by EDP Sciences, 2016
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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