MATEC Web Conf.
Volume 63, 20162016 International Conference on Mechatronics, Manufacturing and Materials Engineering (MMME 2016)
|Number of page(s)||4|
|Section||Materials Science and Engineering|
|Published online||12 July 2016|
Preparation and release kinetics of betulinic acid/ CS drug-loaded microspheres
1 The University Key Laboratory of Fine Chemical Industry of Heilongjiang Province, Chemistry and Chemical Engineering, Qiqihar University, 161006, China
2 School of Material Science and Engineering, Harbin University of Science and Technology, Harbin, 150080, China
Chitosan(CS) is the unique alkaline polysaccharide in nature, because of its perfect biocompatibility and degradability, it is widely used in medicine, soft release and control release. The betulinic acid is the derivative of betulin, it has many pharmacological activities, such as anti- inflammatory, antitumor, anti-malaria and anti-HIV. In this paper, the Span-80 was used as emulsifiers, the glutaraldehyde was used as crosslinker. With the method of orthogonal experiment, the preparation technology was optimized. The microspheres were characterized by SEM and its degree of crosslinking, drug-loading rate and encapsulation efficiency were tested at the same time.
© Owned by the authors, published by EDP Sciences, 2016
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