MATEC Web of Conferences
Volume 60, 20162016 3rd International Conference on Chemical and Biological Sciences
|Number of page(s)||4|
|Published online||08 June 2016|
Effects of Puerarin Derivative P on Learning, Memory and MPO Activity in Vascular Dementia Model Mice
1 Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China
2 Engineering Research Center of Natural Anticancer Drugs, Ministry of Education, Harbin 150076, China
Pharmacological experiments confirmed that Puerarin could not only expand the arterial vessels, increase the local blood flow, but also could protect the myocardium, improve the blood supply of ischemic tissue, which was used to treat the cerebrovascular dementia disease in clinical practice. Its own structure particularity caused the lower bioavailability and poorer solubility. In order to improve the deficiency, the related pharmacological experiments of the newly synthesized puerarin derivative (P), so as to expect the better curative effect than puerarin in the process of treating vascular dementia. The vascular dementia model was established by permanently ligating the common carotid artery in mice. The effects of puerarin derivative (P) on learning and memory in mice by water maze, Y maze and new object discrimination methods; The myeloperoxidase activity in the ischemic cerebral cortex was evaluated in mice by biochemical method. The experimental results showed that the mice spontaneous alternation response accuracy in Y maze could be obviously improved in 100mg/kg puerarin derivative group; In water maze, the swimming time to the safe platform would be significantly decreased in puerarin derivative group. Meanwhile, the MPO activity in the cerebral cortex of dementia mice was significantly decreased in 100mg/kg puerarin derivative group by permanently ligating the unilateral common carotid artery.
© Owned by the authors, published by EDP Sciences, 2016
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.