MATEC Web of Conferences
Volume 7, 2013JA 2013 – Journées Annuelles de la SF2M 2013 / SF2M Annual Meeting 2013
|Number of page(s)||3|
|Section||Colloque 4 : Biomatériaux / Biomaterials|
|Published online||07 November 2013|
Synthesis and fabrication of porous calcium phosphate ceramics for antibacterial bone substitutes
Laboratoire des Matériaux Céramiques et Procédés Associés – Université de Valenciennes et du Hainaut-Cambrésis, ZI du Champ de l'Abbesse, 59600 Maubeuge, France
Calcium phosphate ceramics like hydroxyapatite (HA) are widely used to repair and reconstruct damaged parts of the human skeleton. This material is currently available as injectable cements, granules or macroporous blocks. The most familiar materials are granule shaped ones because their conveniency to be implanted in human body. In this study, a new manufacturing procedure to fabricate dense, microporous and macroporous hydroxyapatite spherical granules based on a lost wax principle and allowing the fabrication of beads with a fully controlled porosity is presented. The HA granules porous structure is used to impregnation by gentamicine and other active substances. The drug and phage releasing kinetics are compared as a function of time and ceramic porosity.
© Owned by the authors, published by EDP Sciences, 2013
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 2.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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