The effectiveness of oximes against organophosphate poisoning

Letter and science, University of California, Davis, 95616 Davis, USA

^* Corresponding author: qmliu@ucdavis.edu

Abstract

Organophosphate compounds (OPs) have been used by human in many ways over years. However, the misuse of organophosphate has been very common because their notorious toxicity. For example, there has a lot of case that people and children handling OPs improperly resulting in casualty and suffering. The main purpose of this research is to understand the basic of treatment of oxime drugs against organophosphate poisoning based on the clinical data and raise awareness of OPs poisoning. It mainly consists of 3 parts about oxime treatment. The first part is introduction of mechanism of oxime treatment. It talks about the mechanism and the studies of effectiveness of oxime against OPs. Then the most concerning problem, aging, is discussed based on the studies of the behavior of OPs inhibited enzymes, which sometimes oxime is incapable to treat during the second part. Last part mainly talked about the solution that scientists have discovered during research that help oxime treatment to be more effective to deal with the problem.