A Novel PbS Nanparticle Based Electrochemical Codeine Sensor
1 Department of Pharmacy, JiangXi University of Traditional Chinese Medicine, JiangXi 330004, China
2 JiangXi Nursing Vocational and Technical College, JiangXi 330004, China
In the present study, we describe an electrochemical sensor for codeine detection by using the DNA aptamers against codeine. In the sensing protocol, a dually-labeled DNA Aptamer probe was designed to belabeled at one end with HS, and at its another end with an dabcyl as anelectrochemical tag to produce electrochemical signal from recongization occurrence. One special electrochemical marker was prepared by modifying PbS nanoparticle with -cyclodextrins (ab. PbS-CD), which employed as electrochemical signal provider and would conjunct with the codeine probe modified electrode through the host–guest recognition of to dabcyl. With codeine adding, aptamer folding allows the PbS-CD into soultion which caused a increased current signal. This sensor have the ability to detect 5.7pM codeine.
© The Authors, published by EDP Sciences, 2016
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