Biocompatible Fluorescent Probe with the Aggregation-induced Emission Characteristic for Live Cell Imaging
1 College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, P. R. China
2 Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding, 071002, P. R. China
3 Key Laboratory of Analytical Science and Technology of Hebei Province, Hebei University, Baoding, 071002, P. R. China
A new kind of biocompatible probe (PEG-TPEFE) with aggregation-induced emission (AIE) characteristic was reported, which was synthesized from fluorene, tetraphenylethylene (TPE) and polyethylene glycol monomethyle ether 1000 (PEG1000). PEGTPEFE can aggregate into nanosphere and emit strong blue fluorescence in aqueous media. Cytotoxicity assay reveals low cytotoxicity and excellent biocompatibility of this nanoprobe. This nanoprobe was internalized and accumulated by live cells and shown high photostability.
Key words: Fluorescent probe / aggregation-induced emission (AIE) / photophysical properties / cellular imaging
© The Authors, published by EDP Sciences, 2016
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