Gold Nanoparticles Covered Hollow SiO2 Nanocapsules for DOX Delivery and Multiple Antitumor
1 No.111 Jiulong Road, Economic and Technology Development Zone, Hefei, Anhui, P.R.China
2 No.39 Xihai Road, Tunxi District Huangshan City, Anhui Province, P.R.China
A chemo and photothermal therapy integrated nanoplatform, DOX-loaded and AuNPs-covered hollow SiO2 nanocapsules (Au-HMSN@DOX), were constructed for enhanced cancer therapy via sequential NIR irradiation. HMSN are used as nanocarriers for drug delivery. AuNPs exhibit an outstanding photothermal effect for increasing the local temperature. Compared with HMSN@DOX, the combination of NIR light-triggered photothermal of AuNPs and Chemotherapy of DOX leads to enhanced antitumor effect and reduced side effect.
© The Authors, published by EDP Sciences, 2016
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