Femtosecond laser fabrication of optofluidic devices for single cell manipulation
1 Istituto di Fotonica e Nanotecnologie, CNR, Piazza Leonardo da Vinci 32, 20133 Milano, Italy
2 Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy
3 Dept. of Electrical, Computer, and Biomedical Engineering, Università di Pavia, Via Ferrata 5A, 27100 Pavia, Italy .
In this work we fabricate and validate two optofludic devices for the manipulation and analysis of single cells. The chips are fabricated by femtosecond laser micromachining exploiting the 3D capabilities of the technique and the inherent perfect alignment between microfluidic channels and optical networks. Both devices have been validated by probing the mechanical properties of different cancer cell lines, which are expected to show different elasticity because of their different metastatic potential.
© Owned by the authors, published by EDP Sciences, 2015
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