Controlled release of encapsulated methylene blue in a multilayered textile coating
1 Unité Matériaux et Transformations (UMET) UMR CNRS 8207, Université de Lille1, France
2 IBMM, UMR CNRS 5247, Université Montpellier 1, Montpellier, France
3 INSERM U 1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France
We studied the formation of multilayered coating incorporating a β-cyclodextrin polyelectrolyte onto a pretreated polyethylene terephthalate (PET) textile in order to obtain reservoir and sustained release properties towards bioactive molecules. This paper describes the alternate deposition by dip-coating onto the textile of chitosan (CHT) and a β-cyclodextrin polyelectrolyte (polyCTR- βCD) according to the layer-by-layer (LbL) principle. Textiles covered with up to 12 layers were characterized by gravimetry, infrared, zetametry. The building of the multilayer system was then achieved including methylene blue (MB) as bioactive model compound, complexed with polyCTR-βCD, and a release study of BM was investigated in batch. The results showed that the release profile of BM could be controlled by the number of layers in the system.
© Owned by the authors, published by EDP Sciences, 2013
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