Preparation and characterization of antithrombogenic chitosan/alginate films with enhanced physical stability by cross-linking using layer-by-layer method
1 School of Integrated Design Engineering, Keio University, Yokohama 223-8522, Japan
2 Department of Ceramic Engineering, Kangnung-wonju National University, 123 Jibyeon-dong, Kangwon-do 210-702, Korea
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We successfully fabricated (chitosan/alginate) (CHI/ALG) multilayer thin film by layer-by-layer (LBL) method. Film durability was enhanced by forming cross-linking using heat treatment, glutaraldehyde, and calcium chloride. Indeed, the adsorption of fibrinogen onto CHI/ALG multilayer thin film was determined by QCM system and it was found that physical stability and protein resistance of CHI/ALG films were improved by cross-linking of the films.
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